PerioTrap is developing an innovative anti-infective drug which will not only treat but also contribute to the eradication of periodontitis, an inflammatory gum disease caused by bacteria. To date, the most relevant therapy option is a painful procedure consisting of the manual removal of plaque within the dental pockets followed by cleansing using either antiseptic solutions or the administration of broad-spectrum antibiotics. PerioTrap’s approach uses its newly developed, selective, small-molecule drugs to target only the disease-causing bacteria without affecting the commensal bacteria. Protecting the commensal bacteria should encourage a shift towards a natural microbiome, thus preventing the reoccurrence of the disease.